VAV

Proto-oncogene vav

domain:The DH domain is involved in interaction with CCPG1.,function:Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.,miscellaneous:'Vav' stands for the sixth letter of the Hebrew alphabet.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK.,tissue specificity:Widely expressed in hematopoietic cells but not in other cell types.,

cell activation, endocytosis, phagocytosis, apoptosis, induction of apoptosis, immune response, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, intracellular signaling cascade, cell death, induction of apoptosis by extracellular signals, membrane invagination, regulation of cell death, positive regulation of cell death,programmed cell death, induction of programmed cell death, membrane organization, vesicle-mediated transport,death, regulation of cell adhesion, regulation of Rho protein signal transduction, T cell activation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of GTPase activity, leukocyte activation, positive regulation of cell adhesion, regulation of Ras protein signal transduction, lymphocyte activation, regulation of small GTPase mediated signal transduction, regulation of hydrolase activity,

Widely expressed in hematopoietic cells but not in other cell types.