CD161 (PTF0104) Mouse mAb
-YF0115
主要信息
Target
CD161
Host Species
Mouse
Reactivity
Human
Applications
FC, IF
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
组成
PBS, pH 7.4
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
浓度
0.5mg/ml
修饰
Unmodified
克隆性
Monoclonal
克隆号
PTF0104
同种型
Mouse IgG1/Kappa
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抗原&靶点信息
特异性:
Endogenous
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基因名称:
KLRB1 CLEC5B NKRP1A
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蛋白名称:
Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)
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别名:
KLRB1 ;
CLEC5B ;
NKRP1A ;
Killer cell lectin-like receptor subfamily B member 1 ;
C-type lectin domain family 5 member B ;
HNKR-P1a ;
NKR-P1A ;
Natural killer cell surface protein P1A ;
CD161
CLEC5B ;
NKRP1A ;
Killer cell lectin-like receptor subfamily B member 1 ;
C-type lectin domain family 5 member B ;
HNKR-P1a ;
NKR-P1A ;
Natural killer cell surface protein P1A ;
CD161
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背景:
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
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功能:
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.,induction:By IL12 in NK cells.,online information:NKRP1,PTM:N-glycosylated. Contains sialic acid residues.,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.,tissue specificity:Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.,
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细胞定位:
Membrane ; Single-pass type II membrane protein .
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