PLCG2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 ;
Phosphoinositide phospholipase C-gamma-2 ;
Phospholipase C-IV ;
PLC-IV ;
Phospholipase C-gamma-2 ;
PLC-gamma-2 ;

catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,

cell activation, response to molecule of bacterial origin, activation of immune response, cell activation during immune response, lymphocyte activation during immune response, B cell activation during immune response, mature B cell differentiation during immune response, follicular B cell differentiation, mature B cell differentiation, leukocyte activation during immune response, immune response-activating cell surface receptor signaling pathway, immune system development, leukocyte differentiation, positive regulation of immune system process, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, inositol metabolic process, inositol biosynthetic process, phospholipid metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, immune response,cell surface receptor linked signal transduction, elevation of cytosolic calcium ion concentration, intracellular signaling cascade, phospholipid catabolic process, response to bacterium, response to organic substance, response to inorganic substance, response to metal ion, regulation of cell death, regulation of metal ion transport, lipid catabolic process, carbohydrate biosynthetic process, organophosphate metabolic process, cellular homeostasis, polyol metabolic process, regulation of transmembrane transporter activity, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, hemopoiesis, lymphocyte differentiation, B cell differentiation, response to magnesium ion, regulation of calcium ion transport via store-operated calcium channel activity, positive regulation of calcium ion transport via store-operated calcium channel activity, activation of store-operated calcium channel activity, regulation of transporter activity, positive regulation of transporter activity, regulation of ion transmembrane transporter activity,positive regulation of ion transmembrane transporter activity, response to lipopolysaccharide, inositol trisphosphate metabolic process, inositol phosphate biosynthetic process, inositol trisphosphate biosynthetic process, response to ATP, cellular carbohydrate biosynthetic process, regulation of transmembrane transport, regulation of ion transmembrane transport, B cell activation, homeostatic process, regulation of programmed cell death, negative regulation of programmed cell death, regulation of ion transport, positive regulation of ion transport, inositol phosphate metabolic process, positive regulation of molecular function, cellular lipid catabolic process, leukocyte activation, alcohol biosynthetic process, polyol biosynthetic process, lymphocyte activation, hemopoietic or lymphoid organ development, positive regulation of response to stimulus, chemical homeostasis, positive regulation of immune response, ion homeostasis, antigen receptor-mediated signaling pathway, T cell receptor signaling pathway, positive regulation of transport, cytosolic calcium ion homeostasis, regulation of calcium ion transport, positive regulation of calcium ion transport, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis,cation homeostasis, cellular chemical homeostasis, negative regulation of cell death,