CDK2

Cyclin-dependent kinase 2 ;
Cell division protein kinase 2 ;
p33 protein kinase ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it.,function:Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1.,

G1 phase of mitotic cell cycle, G2/M transition of mitotic cell cycle, M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division, DNA metabolic process, DNA replication, regulation of DNA replication, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, ion transport, cation transport,potassium ion transport, cell cycle, mitosis, traversing start control point of mitotic cell cycle, regulation of mitotic cell cycle, positive regulation of cell proliferation, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, monovalent inorganic cation transport, phosphorylation, cell cycle process, cell cycle phase, metal ion transport, positive regulation of cellular biosynthetic process, regulation of cell proliferation, regulation of transcription, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, organelle fission, regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process, cell division, G1 phase, interphase, interphase of mitotic cell cycle, regulation of cell cycle,

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).