AAPK1/AAPK2

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Binding of AMP results in allosteric activation, inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio.,function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.,

MAPKKK cascade, activation of MAPK activity, response to hypoxia, monosaccharide metabolic process, glucose metabolic process, protein amino acid phosphorylation, fatty acid metabolic process, fatty acid biosynthetic process,steroid biosynthetic process, cholesterol biosynthetic process, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, steroid metabolic process, cholesterol metabolic process, lipid biosynthetic process, negative regulation of biosynthetic process, positive regulation of biosynthetic process, regulation of cellular ketone metabolic process, positive regulation of steroid biosynthetic process, organic acid biosynthetic process, sterol metabolic process, sterol biosynthetic process, phosphorylation, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of steroid metabolic process, regulation of phosphate metabolic process, hexose metabolic process, fatty acid oxidation, lipid modification, negative regulation of cellular biosynthetic process, positive regulation of kinase activity, lipid oxidation, regulation of phosphorylation,positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity,regulation of kinase activity, regulation of cellular component biogenesis, positive regulation of molecular function,regulation of cholesterol biosynthetic process, positive regulation of cholesterol biosynthetic process, regulation of anti-apoptosis, positive regulation of anti-apoptosis, negative regulation of lipid metabolic process, positive regulation of lipid metabolic process, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of steroid metabolic process, regulation of glucosylceramide biosynthetic process, negative regulation of glucosylceramide biosynthetic process, regulation of fatty acid oxidation, carboxylic acid biosynthetic process, positive regulation of lipid biosynthetic process, regulation of lipid biosynthetic process, regulation of steroid biosynthetic process, negative regulation of lipid biosynthetic process, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, response to oxygen levels,

Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .