IGF1R

Insulin-like growth factor 1 receptor ;
Insulin-like growth factor I receptor ;
IGF-I receptor ;
CD antigen CD221 ;
[Cleaved into: Insulin-like growth factor 1 receptor alpha chain ;
Insulin-like growth factor 1 receptor beta chain]

cell morphogenesis, cell morphogenesis involved in differentiation, reproductive developmental process, regulation of DNA replication, protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, anti-apoptosis, immune response, establishment or maintenance of cell polarity, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade,axonogenesis, sex determination, positive regulation of cell proliferation, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, response to organic substance, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, regulation of cell death, phosphoinositide 3-kinase cascade, phosphorylation, second-messenger-mediated signaling, establishment of cell polarity, cell projection organization, neuron differentiation, male sex determination, regulation of cell migration, positive regulation of cell migration, mammary gland development, neuron projection development, positive regulation of cellular biosynthetic process, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, cellular component morphogenesis, cell part morphogenesis, regulation of locomotion, positive regulation of locomotion, regulation of cell proliferation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, response to peptide hormone stimulus, macromolecular complex subunit organization,positive regulation of DNA replication, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein amino acid autophosphorylation, insulin-like growth factor receptor signaling pathway,phosphoinositide-mediated signaling, neuron development, cell morphogenesis involved in neuron differentiation,gland development, neuron projection morphogenesis, cell projection morphogenesis, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process,protein oligomerization, protein tetramerization, regulation of cell motion, positive regulation of cell motion, protein heterooligomerization, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,

Cell membrane ; Single-pass type I membrane protein .

Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.