EGFR

EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EGFR are associated with lung cancer [MIM:211980].,function:Isoform 2/truncated isoform may act as an antagonist.,function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.,online information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1.,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.,

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, MAPKKK cascade, activation of MAPKK activity, mitotic cell cycle, cell morphogenesis, skeletal system development, ossification, cell activation,regulation of protein amino acid phosphorylation, translation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to osmotic stress, response to oxidative stress, cell cycle,cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, activation of phospholipase C activity, intracellular signaling cascade, protein kinase cascade, regulation of mitotic cell cycle, sensory organ development, salivary gland development, salivary gland morphogenesis, circadian rhythm, protein localization, cell proliferation, positive regulation of cell proliferation, response to radiation, response to UV, response to light stimulus, response to abiotic stimulus, positive regulation of biosynthetic process, glial cell differentiation, response to organic substance, response to inorganic substance, response to metal ion, regulation of phospholipase activity, positive regulation of phospholipase activity, positive regulation of phosphorus metabolic process, positive regulation of cell communication, positive regulation of phospholipase C activity, regulation of cell death, astrocyte development, membrane organization, phosphorylation, cell-cell adhesion, regulation of phosphate metabolic process, calcium-mediated signaling, second-messenger-mediated signaling, glial cell development, cell cycle process, cell cycle phase, biological adhesion, gland morphogenesis, cell projection organization, neuron differentiation, regulation of cell migration, positive regulation of cell migration, neuron projection development,positive regulation of cellular biosynthetic process, regulation of protein modification process, regulation of neurological system process, positive regulation of neurological system process, regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of cyclin-dependent protein kinase activity during G1/S,activation of protein kinase activity, regulation of cellular protein metabolic process, regulation of phospholipase A2 activity, positive regulation of phospholipase A2 activity, activation of phospholipase A2 activity, multicellular organism reproduction, regulation of monooxygenase activity, cellular component morphogenesis, cell part morphogenesis,positive regulation of kinase activity, response to lipid, cellular protein localization, exocrine system development,regulation of locomotion, positive regulation of locomotion, gliogenesis, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, ovulation cycle, regulation of apoptosis, activation of phospholipase A2 activity by calcium-mediated signaling, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, tongue development, regulation of system process, positive regulation of molecular function, regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of cyclin-dependent protein kinase activity, negative regulation of cell cycle, positive regulation of cell cycle, regulation of protein kinase activity, positive regulation of protein kinase activity, negative regulation of mitotic cell cycle, positive regulation of phosphate metabolic process,protein amino acid autophosphorylation, astrocyte activation, rhythmic process, reproductive process in a multicellular organism, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, neuron development, astrocyte differentiation, gland development, neuron projection morphogenesis, cell projection morphogenesis, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, regulation of peptidyl-tyrosine phosphorylation, regulation of synaptic transmission, positive regulation of synaptic transmission,regulation of nitric-oxide synthase activity, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, protein insertion into membrane, positive regulation of multicellular organismal process, regulation of cell motion, positive regulation of cell motion, interphase, interphase of mitotic cell cycle,regulation of hydrolase activity, regulation of transferase activity, regulation of oxidoreductase activity, positive regulation of hydrolase activity, positive regulation of transferase activity, response to calcium ion, localization within membrane, regulation of cell cycle, regulation of synaptic transmission, glutamatergic, positive regulation of synaptic transmission, glutamatergic, regulation of transmission of nerve impulse, positive regulation of transmission of nerve impulse, regulation of lipase activity, positive regulation of lipase activity, bone development, negative regulation of cell death, response to UV-A, cellular macromolecule localization,

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.

Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.