DAB1

DAB1 ;
Disabled homolog 1

domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.,

neuron migration, cell motion, cell adhesion, negative regulation of cell adhesion, intracellular signaling cascade, small GTPase mediated signal transduction, cell-cell adhesion, cell migration, regulation of phosphate metabolic process, cell migration in hindbrain, telencephalon development, pallium development, cerebellum development, hindbrain morphogenesis, hindbrain structural organization, cerebellum morphogenesis, cerebellum structural organization,cerebral cortex cell migration, cerebral cortex radially oriented cell migration, cerebral cortex radial glia guided migration, neuronal-glial interaction involved in cerebral cortex radial glia guided migration, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, forebrain cell migration, hindbrain radial glia guided cell migration, radial glia guided migration of Purkinje cell, cerebral cortex development,telencephalon cell migration, metencephalon development, biological adhesion, regulation of cell adhesion, forebrain development, hindbrain development, positive regulation of kinase activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, anatomical structure arrangement, cell motility,regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, localization of cell,

Mainly expressed in brain.