YWHAQ

14-3-3 protein theta ;
14-3-3 protein T-cell ;
14-3-3 protein tau ;
Protein HS1 ;

function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,similarity:Belongs to the 14-3-3 family.,subcellular location:In neurons, axonally transported to the nerve terminals.,subunit:Homodimer. Interacts with PCTK1 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm.,tissue specificity:Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.,

regulation of transcription, DNA-dependent, protein targeting, intracellular protein transport, intracellular signaling cascade, small GTPase mediated signal transduction, protein localization, negative regulation of biosynthetic process,negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process,negative regulation of gene expression, protein transport, negative regulation of transcription, negative regulation of cellular biosynthetic process, cellular protein localization, establishment of protein localization, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, intracellular transport, negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, cellular macromolecule localization,

Cytoplasm. In neurons, axonally transported to the nerve terminals.

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.