domain:Comprised of 3 domains; an N-terminal DNA-binding domain , a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression. ,function:Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. ,PTM:Phosphorylated by NLK on multiple sites , which induces proteasomal degradation. ,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. ,similarity:Contains 3 HTH myb-type DNA-binding domains. ,subunit:Binds MYBBP1A. Interacts with HIPK2 , MAF and NLK. ,
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