Synthesized peptide derived from human Histone H2B (Acetyl Lys86)

This antibody detects endogenous levels of Human,Mouse,Rat Histone H2B (Acetyl Lys86).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YNkRS

HIST1H2BB H2BFF

Histone H2B (Acetyl Lys86)

Histone H2B type 1-B ;
Histone H2B.1 ;
Histone H2B.f ;
H2B/f ;

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A , H2B , H3 , and H4) . The chromatin fiber is further compacted through the interaction of a linker histone , H1 , with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead , they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq , Aug 2015] ,

Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin , limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation , DNA repair , DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones , also called histone code , and nucleosome remodeling. ,PTM:Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. ,PTM:Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs) , and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. ,similarity:Belongs to the histone H2B family. ,subunit:The nucleosome is a histone octamer containing two molecules each of H2A , H2B , H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. ,

Nucleus. Chromosome.

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