Synthesized peptide derived from human Cdk9 (Acetyl Lys44)

This antibody detects endogenous levels of Human Cdk9 (Acetyl Lys44).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GQkVA

CDK9 CDC2L4 TAK

Cdk9 (Acetyl Lys44)

Cyclin-dependent kinase 9 ;
EC 2.7.11.23 ;
C-2K ;
Cell division cycle 2-like protein kinase 4 ;
Cell division protein kinase 9 ;
Serine/threonine-protein kinase PITALRE ;
Tat-associated kinase complex catalytic subunit ;

cyclin dependent kinase 9 (CDK9) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28 , and S. pombe cdc2 , and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb , which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T , which suggested a possible involvement of this protein in AIDS. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. ,Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex , also called positive transcription elongation factor b (P-TEFb) , which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) , SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates with CCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1 , P-TEFb complex , RNA pol II , SUPT5H , and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) , HEXIM1 , HEXIM2 , BCDIN3 , SART3 proteins and 7SK and U6 snRNAs. ,tissue specificity:Ubiquitous. ,

Nucleus. Cytoplasm. Nucleus , PML body. Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles , but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.

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