BACE (Acetyl Lys316) Rabbit pAb
-YK0101
主要信息
Target
BACE Acetyl Lys316
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
55kD (Observed)
Conjugate/Modification
Acetyl
货号: YK0101
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human,Mouse,Rat BACE (Acetyl Lys316).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LRkGV
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Acetyl
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human BACE (Acetyl Lys316)
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特异性:
This antibody detects endogenous levels of Human,Mouse,Rat BACE (Acetyl Lys316).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LRkGV
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基因名称:
BACE1 BACE KIAA1149
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蛋白名称:
BACE (Acetyl Lys316)
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别名:
Beta-secretase 1 ;
Aspartyl protease 2 ;
ASP2 ;
Asp 2 ;
Beta-site amyloid precursor protein cleaving enzyme 1 ;
Beta-site APP cleaving enzyme 1 ;
Memapsin-2 ;
Membrane-associated aspartic protease 2 ;
Aspartyl protease 2 ;
ASP2 ;
Asp 2 ;
Beta-site amyloid precursor protein cleaving enzyme 1 ;
Beta-site APP cleaving enzyme 1 ;
Memapsin-2 ;
Membrane-associated aspartic protease 2 ;
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背景:
beta-secretase 1 (BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants , at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques , which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq , Nov 2015] ,
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功能:
Catalytic activity:Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. ,enzyme regulation:Inhibited by RTN3 and RTN4. ,Function:Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves at the N-terminus of the A-beta peptide sequence , between residues 671 and 672 of APP , leads to the generation and extracellular release of beta-cleaved soluble APP , and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. ,similarity:Belongs to the peptidase A1 family. ,subunit:Monomer. Interacts with GGA1 , GGA2 and GGA3. Interacts with RTN3 and RTN4. ,tissue specificity:Brain. ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein . Golgi apparatus , trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection , axon . Cell projection , dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum , endosomes and on the cell surface (PubMed:17425515 , PubMed:11466313) . Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity) . Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016) . .
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研究领域:
>>Alzheimer disease
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货号: YK0101
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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