ATF-4 (Phospho Ser219) Rabbit pAb
-YP0503
主要信息
Target
CREB-2 Phospho Ser219
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
38kD (Observed)
Conjugate/Modification
Phospho
货号: YP0503
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
Western Blot: 1/500-1/2000; ELISA 1/10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-CREB-2 (S219) Polyclonal Antibody detects endogenous levels of CREB-2 protein only when phosphorylated at S219.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NDsGI
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-20°C/1 year,Ship by ice bag
浓度
1 mg/ml
实测条带
38kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
免疫原:
Synthesized phospho-peptide around the phosphorylation site of human CREB-2 (phospho Ser219)
展开内容
特异性:
Phospho-CREB-2 (S219) Polyclonal Antibody detects endogenous levels of CREB-2 protein only when phosphorylated at S219.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NDsGI
展开内容
基因名称:
ATF4
展开内容
蛋白名称:
Cyclic AMP-dependent transcription factor ATF-4
展开内容
别名:
ATF4 ;
CREB2 ;
TXREB ;
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding prot
CREB2 ;
TXREB ;
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding prot
展开内容
背景:
activating transcription factor 4 (ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors , cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions , located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid
展开内容
功能:
Function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') , a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. ,similarity:Belongs to the bZIP family. ,similarity:Contains 1 bZIP domain. ,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. ,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity) . Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290. ,
展开内容
细胞定位:
Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity) . Colocalizes with NEK6 at the centrosome (PubMed:20873783) . Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772) . .
展开内容
信号通路
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Endocrine system >> Insulin secretion
Organismal Systems >> Endocrine system >> Glucagon signaling pathway
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Endocrine system >> Relaxin signaling pathway
Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Organismal Systems >> Nervous system >> Cholinergic synapse
Organismal Systems >> Nervous system >> Dopaminergic synapse
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Organismal Systems >> Aging >> Longevity regulating pathway
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
文献引用（{{totalcount}}）
货号: YP0503
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}