Synthesized peptide derived from human CSFR (Phospho Tyr921)

This antibody detects endogenous levels of CSFR (Phospho Tyr921) Rabbit pAb at Human, Mouse,Rat

CSF1R FMS

Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (Proto-oncogene c-Fms) (CD antigen CD115)

Macrophage colony-stimulating factor 1 receptor ;
CSF-1 receptor ;
CSF-1-R ;
CSF-1R ;
M-CSF-R ;
Proto-oncogene c-Fms ;
CD antigen CD115 ;

colony stimulating factor 1 receptor (CSF1R) Homo sapiens The protein encoded by this gene is the receptor for colony stimulating factor 1 , a cytokine which controls the production , differentiation , and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Dec 2013] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts with INPPL1/SHIP2 and THOC5. ,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells. ,

Cell membrane; Single-pass type I membrane protein.

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>PI3K-Akt signaling pathway ;
>>Osteoclast differentiation ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia