Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys12)

This antibody detects endogenous levels of Human,Mouse,Rat Histone H2A.Z (Acetyl Lys12).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SGkAK

H2AFZ H2AZ

Histone H2A.Z (Acetyl Lys12)

Histone H2A.Z ;
H2A/z ;

function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.,mass spectrometry:Monoisotopic, not modified PubMed:16457589,PTM:Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.,PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.,PTM:Not phosphorylated.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.,

DNA packaging, chromatin organization, chromatin assembly or disassembly, nucleosome assembly, chromatin assembly, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly,nucleosome organization, macromolecular complex subunit organization, chromosome organization, macromolecular complex assembly, protein-DNA complex assembly,

Nucleus. Chromosome.

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