EPHA2 (Phospho Tyr930) Rabbit pAb
-YP1818
主要信息
Target
EphA2 Phospho Tyr930
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, WB
MW
130kD (Observed)
Conjugate/Modification
Phospho
货号: YP1818
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-200
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of EPHA2 (Phospho Tyr930) Rabbit pAb at Human, Mouse.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AGyTA
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
130kD
修饰
Phospho
克隆性
Polyclonal
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human EPHA2 (Phospho Tyr930)
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特异性:
This antibody detects endogenous levels of EPHA2 (Phospho Tyr930) Rabbit pAb at Human, Mouse.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AGyTA
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基因名称:
EPHA2 ECK
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蛋白名称:
Ephrin type-A receptor 2 (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
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别名:
EPHA2 ;
ECK ;
Ephrin type-A receptor 2 ;
Epithelial cell kinase ;
Tyrosine-protein kinase receptor ECK
ECK ;
Ephrin type-A receptor 2 ;
Epithelial cell kinase ;
Tyrosine-protein kinase receptor ECK
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背景:
EPH receptor A2 (EPHA2) Homo sapiens This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events , particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq , May 2010] ,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A1 , -A3 , -A4 and -A5. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SAM (sterile alpha motif) domain. ,similarity:Contains 2 fibronectin type-III domains. ,subunit:Interacts with SLA (By similarity) . Interacts with INPPL1/SHIP2. ,tissue specificity:Expressed most highly in tissues that contain a high proportion of epithelial cells , e.g. , skin , intestine , lung , and ovary. ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein . Cell projection , ruffle membrane ; Single-pass type I membrane protein . Cell projection , lamellipodium membrane ; Single-pass type I membrane protein . Cell junction , focal adhesion . Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808 , PubMed:20861311) . Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797) . .
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研究领域:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Axon guidance
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Axon guidance
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信号通路
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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货号: YP1818
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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