Synthesized peptide derived from human IRE1 thr973

This antibody detects endogenous levels of IRE1 thr973 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PVtPD

ERN1 IRE1

IRE1 thr973

ERN1 ;
IRE1 ;
Serine/threonine-protein kinase/endoribonuclease IRE1 ;
Endoplasmic reticulum-to-nucleus signaling 1 ;
Inositol-requiring protein 1 ;
hIRE1p ;
Ire1-alpha ;
IRE1a

The protein encoded by this gene is the ER to nucleus signalling 1 protein , a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. ,Function:Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus , converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. ,PTM:Autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ,similarity:Contains 1 KEN domain. ,similarity:Contains 1 protein kinase domain. ,subunit:Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5 , a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. ,tissue specificity:Ubiquitously expressed. High levels observed in pancreatic tissue. ,

Endoplasmic reticulum membrane ; Single-pass type I membrane protein .

>>Autophagy - animal ;
>>Protein processing in endoplasmic reticulum ;
>>Apoptosis ;
>>Non-alcoholic fatty liver disease ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Lipid and atherosclerosis