Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

THPO

Thrombopoietin

THPO ;
MGDF ;
Thrombopoietin ;
C-mpl ligand ;
ML ;
Megakaryocyte colony-stimulating factor ;
Megakaryocyte growth and development factor ;
MGDF ;
Myeloproliferative leukemia virus oncogene ligand

disease:Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.,domain:Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.,function:Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.,similarity:Belongs to the EPO/TPO family.,

response to molecule of bacterial origin, immune system development, cell proliferation, positive regulation of cell proliferation, response to bacterium, response to organic substance, hemopoiesis, myeloid cell differentiation,response to lipopolysaccharide, regulation of cell proliferation, hemopoietic or lymphoid organ development,

Secreted.