Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

THBD

Thrombomodulin

THBD ;
THRM ;
Thrombomodulin ;
TM ;
Fetomodulin ;
CD antigen CD141

disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin.,

response to molecule of bacterial origin, female pregnancy, blood coagulation, hemostasis, response to radiation,response to wounding, response to bacterium, response to abiotic stimulus, response to organic substance, response to X-ray, response to ionizing radiation, response to lipopolysaccharide, wound healing, coagulation, regulation of body fluid levels, response to cAMP,

Membrane; Single-pass type I membrane protein.

Endothelial cells are unique in synthesizing thrombomodulin.