Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

PDGFA/PDGFB

Platelet-derived growth factor subunit A/Platelet-derived growth factor subunit B

PDGFA ;
PDGF1 ;
Platelet-derived growth factor subunit A ;
PDGF subunit A ;
PDGF-1 ;
Platelet-derived growth factor A chain ;
Platelet-derived growth factor alpha polypeptide ;
PDGFB ;
PDGF2 ;
SIS ;
Platelet-derived growth factor subunit B ;
PDGF subu

domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,

angiogenesis, blood vessel development, response to hypoxia, cell activation, regulation of protein amino acid phosphorylation, hair follicle development, vasculature development, positive regulation of mesenchymal cell proliferation, regulation of DNA replication, chemotaxis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway,transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, cell-cell signaling, ectoderm development, sensory organ development, response to nutrient,behavior, locomotory behavior, cell proliferation, positive regulation of cell proliferation, epidermis development,response to wounding, response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to extracellular stimulus, response to organic substance, response to inorganic substance, regulation of mesenchymal cell proliferation, regulation of phosphatidylinositol biosynthetic process, negative regulation of phosphatidylinositol biosynthetic process, regulation of platelet activation, negative regulation of platelet activation, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, regulation of smooth muscle cell migration,regulation of lipid metabolic process, regulation of phosphate metabolic process, molting cycle process, hair cycle process, cell projection organization, cell projection assembly, regulation of blood coagulation, negative regulation of blood coagulation, respiratory tube development, lung development, regulation of cell migration, positive regulation of cell migration, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process,regulation of protein modification process, response to nutrient levels, regulation of response to external stimulus,regulation of cellular protein metabolic process, response to estradiol stimulus, response to retinoic acid, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of organelle organization,response to vitamin A, response to vitamin, tube development, regulation of locomotion, positive regulation of locomotion, wound healing, regulation of cell proliferation, molting cycle, regulation of phosphorylation, taxis, response to drug, hair cycle, ear development, skin development, response to estrogen stimulus, positive regulation of DNA replication, negative regulation of lipid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of lipid biosynthetic process, platelet-derived growth factor receptor signaling pathway, regulation of fibroblast proliferation, positive regulation of fibroblast proliferation, lung alveolus development, blood vessel morphogenesis, response to steroid hormone stimulus, inner ear development, regulation of peptidyl-tyrosine phosphorylation, regulation of coagulation, negative regulation of coagulation, regulation of cell activation, negative regulation of cell activation, negative chemotaxis, regulation of DNA metabolic process, positive regulation of DNA metabolic process, negative regulation of lipid biosynthetic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, negative regulation of multicellular organismal process, regulation of cell motion, positive regulation of cell motion, regulation of cell division, regulation of cytoskeleton organization, positive regulation of cell division, respiratory system development, response to oxygen levels,

Secreted. Released by platelets upon wounding.