Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

MIF

Macrophage migration inhibitory factor

MIF ;
GLIF ;
MMIF ;
Macrophage migration inhibitory factor ;
MIF ;
Glycosylation-inhibiting factor ;
GIF ;
L-dopachrome isomerase ;
L-dopachrome tautomerase ;
Phenylpyruvate tautomerase

catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate.,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,similarity:Belongs to the MIF family.,subunit:Homotrimer. Interacts with COPS5 and BNIPL.,

prostaglandin biosynthetic process, regulation of leukocyte activation, protein complex assembly, fatty acid metabolic process, fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process, icosanoid metabolic process,prostanoid metabolic process, prostaglandin metabolic process, defense response, inflammatory response, immune response, cell surface receptor linked signal transduction, cell proliferation, lipid biosynthetic process, response to wounding, regulation of cell death, organic acid biosynthetic process, unsaturated fatty acid metabolic process,regulation of apoptosis, regulation of macrophage activation, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, macromolecular complex subunit organization,innate immune response, carboxylic acid biosynthetic process, icosanoid biosynthetic process, prostanoid biosynthetic process, regulation of cell activation, protein oligomerization, protein homooligomerization, negative regulation of cell death, macromolecular complex assembly, protein trimerization, protein homotrimerization, protein complex biogenesis,

Secreted . Cytoplasm . Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. .