Synthesized peptide derived from human RSK2 (Phospho-Tyr529)

This antibody detects endogenous levels of RSK2 (Phospho-Tyr529) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VEyLH

RPS6KA3 ISPK1 MAPKAPK1B RSK2

RSK2 (Phospho-Tyr529)

Ribosomal protein S6 kinase alpha-3 ;
S6K-alpha-3 ;
90 kDa ribosomal protein S6 kinase 3 ;
p90-RSK 3 ;
p90RSK3 ;
Insulin-stimulated protein kinase 1 ;
ISPK-1 ;
MAP kinase-activated protein kinase 1b ;
MAPK-activated protein kinase 1b ;
MAPKAP kinase 1b ;
MAPKAPK-1b ;
Ribosomal S6 kinase 2 ;
RSK-2 ;
pp90RSK2 ;

ribosomal protein S6 kinase A3 (RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates , including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS) . [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms , and progressive skeletal deformations. ,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues. ,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. ,PTM:Autophosphorylated on Ser-386 , as part of the activation process. ,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 2 protein kinase domains. ,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity) . Interacts with NFATC4. ,tissue specificity:Expressed in many tissues , highest levels in skeletal muscle. ,

Nucleus . Cytoplasm .

>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation