Function:May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites , ME1a1 and ME1a2 , within the c-myc promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. ,similarity:Contains 6 C2H2-type zinc fingers. ,subcellular location:In brains of Alzheimer disease patients , present in a plaque-like structures. ,subunit:Interacts with BPTF. ,tissue specificity:Present in kidney , liver and brain. In the brain , highest levels are found in motor cortex and midfrontal cortex (at protein level) . ,
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