Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FOLR1

Folate receptor alpha

FOLR1 ;
FOLR ;
Folate receptor alpha ;
FR-alpha ;
Adult folate-binding protein ;
FBP ;
Folate receptor 1 ;
Folate receptor ;
adult ;
KB cells FBP ;
Ovarian tumor-associated antigen MOv18

function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.,PTM:Eight disulfide bonds are present.,PTM:The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.,similarity:Belongs to the folate receptor family.,tissue specificity:Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.,

coenzyme metabolic process, folic acid and derivative metabolic process, vitamin metabolic process, water-soluble vitamin metabolic process, amino acid transport, endocytosis, receptor-mediated endocytosis, membrane invagination,amine transport, organic acid transport, folic acid transport, membrane organization, vesicle-mediated transport,pteridine and derivative metabolic process, folic acid metabolic process, carboxylic acid transport, vitamin transport,cofactor transport, cofactor metabolic process, transmembrane transport,

Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. .

Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.