ACK1 (Phospho Tyr857/858) Rabbit pAb
-YP1763
主要信息
Target
ACK Phospho Tyr857/858
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
114kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1763
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous Phospho Ack1 levels of around : Human :Y857 or Y858, Mouse:Y874 or Y875, Rat:Y859 or Y860,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HyyLL
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
114kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized peptide derived from human Ack1 (Phospho-Tyr857+Tyr858)
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特异性:
This antibody detects endogenous Phospho Ack1 levels of around : Human :Y857 or Y858, Mouse:Y874 or Y875, Rat:Y859 or Y860,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HyyLL
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基因名称:
TNK2 ACK1
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蛋白名称:
Ack1 (Phospho-Tyr857+Tyr858)
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别名:
TNK2 ;
ACK1 ;
Activated CDC42 kinase 1 ;
ACK-1 ;
Tyrosine kinase non-receptor protein 2
ACK1 ;
Activated CDC42 kinase 1 ;
ACK-1 ;
Tyrosine kinase non-receptor protein 2
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背景:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene , but the full-length nature of only two transcript variants has been determined. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,cofactor:Magnesium. ,enzyme regulation:The SH3 domain appears to play an autoinhibitory role. ,Function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development. ,sequence Caution:Unlikely isoform. Aberrant splice sites. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Contains 1 CRIB domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH3 domain. ,subunit:Interacts with CDC42. Interacts with activated CSPG4. ,
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细胞定位:
Cell membrane . Nucleus . Endosome . Cell junction , adherens junction . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle , clathrin-coated vesicle . Membrane , clathrin-coated pit . Cytoplasm , perinuclear region . Cytoplasm , cytosol . The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity) . Co-localizes with EGFR on endosomes (PubMed:20333297) . Nuclear translocation is CDC42-dependent (By similarity) . Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity) . .
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货号: YP1763
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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