Synthesized peptide derived from human EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)

This antibody detects endogenous levels of EPHB1/2/3/4 only when phosphorylated at Tyr600/602/614/596..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):FTyED

EPHB1 ELK EPHT2 HEK6 NET

EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)

EPHB1 ;
ELK ;
EPHT2 ;
HEK6 ;
NET ;
Ephrin type-B receptor 1 ;
ELK ;
EPH tyrosine kinase 2 ;
EPH-like kinase 6 ;
EK6 ;
hEK6 ;
Neuronally-expressed EPH-related tyrosine kinase ;
NET ;
Tyrosine-protein kinase receptor EPH-2 ;
EPHB2 ;
DRT ;
EPHT3 ;
EPTH3 ;
ERK ;

Ephrin receptors and their ligands , the ephrins , mediate numerous developmental processes , particularly in the nervous system. Based on their structures and sequence relationships , ephrins are divided into the ephrin-A (EFNA) class , which are anchored to the membrane by a glycosylphosphatidylinositol linkage , and the ephrin-B (EFNB) class , which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for members of the ephrin-B family. Binds to ephrin-B1 , -B2 and -B3. May be involved in cell-cell interactions in the nervous system. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SAM (sterile alpha motif) domain. ,similarity:Contains 2 fibronectin type-III domains. ,subunit:The ligand-activated form interacts with GRB2 , GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928 , while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP. ,tissue specificity:Preferentially expressed in brain. ,

Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection , dendrite .

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