Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CX3CL1

Fractalkine

CX3CL1 ;
FKN ;
NTT ;
SCYD1 ;
A-152E5.2 ;
Fractalkine ;
C-X3-C motif chemokine 1 ;
CX3C membrane-anchored chemokine ;
Neurotactin ;
Small-inducible cytokine D1

function:The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.,induction:By TNF and IL-1 in pulmonary endothelial cells and umbilical vein endothelial cells.,online information:CX3CL1 entry,PTM:A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.,similarity:Belongs to the intercrine delta family.,subunit:Monomer.,tissue specificity:Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.,

cell activation, cell motion, chemotaxis, defense response, immune response, cell adhesion, behavior, locomotory behavior, cell migration, cytokine-mediated signaling pathway, regulation of cell-cell adhesion, positive regulation of cell-cell adhesion, biological adhesion, regulation of cell adhesion, leukocyte chemotaxis, positive regulation of defense response, regulation of response to external stimulus, positive regulation of response to external stimulus, taxis,cellular extravasation, leukocyte activation, positive regulation of cell adhesion, positive regulation of response to stimulus, cell motility, regulation of inflammatory response, positive regulation of inflammatory response, leukocyte migration, leukocyte adhesive activation, regulation of calcium-independent cell-cell adhesion, positive regulation of calcium-independent cell-cell adhesion, localization of cell, cell chemotaxis,

Cell membrane ; Single-pass type I membrane protein .; [Processed fractalkine]: Secreted .

Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.