Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CORIN

Atrial natriuretic peptide-converting enzyme

CORIN ;
CRN ;
TMPRSS10 ;
Atrial natriuretic peptide-converting enzyme ;
Corin ;
Heart-specific serine proteinase ATC2 ;
Pro-ANP-converting enzyme ;
Transmembrane protease serine 10

function:Converts Pro-ANP to ANP. Cleaves Pro-ANP specifically between 'Arg-123' and 'Ser-124'.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,similarity:Contains 2 FZ (frizzled) domains.,similarity:Contains 7 LDL-receptor class A domains.,tissue specificity:Highly expressed in heart. Expressed in heart myocytes.,

circulatory system process, proteolysis, blood circulation, regulation of blood pressure, protein processing, protein maturation, protein maturation by peptide bond cleavage,

Cell membrane ; Single-pass type II membrane protein . May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Soluble form produced following autocatalytic cleavage.

Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).