NDR1/2 (Phospho Thr444/442) Rabbit pAb
-YP1749
主要信息
Target
STK38 Phospho Thr444/442
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
51kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1749
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of STK38 only when phosphorylated at Human:T444/442, Mouse:T444/442..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NYtYK
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
51kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized peptide derived from human NDR1/2 (Phospho-Thr444/442)
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特异性:
This antibody detects endogenous levels of STK38 only when phosphorylated at Human:T444/442, Mouse:T444/442..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NYtYK
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基因名称:
STK38 NDR1
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蛋白名称:
NDR1/2 (Phospho-Thr444/442)
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别名:
Serine/threonine-protein kinase 38 ;
NDR1 protein kinase ;
Nuclear Dbf2-related kinase 1 ;
NDR1 protein kinase ;
Nuclear Dbf2-related kinase 1 ;
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背景:
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Feb 2015] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions , enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Low levels present in the cytoplasm. ,subunit:Homodimeric S100B binds two molecules of STK38. Interacts with MOB1 and MOB2. ,tissue specificity:Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. ,
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细胞定位:
Nucleus. Cytoplasm.
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文献引用（{{totalcount}}）
货号: YP1749
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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