MKP-3 (Phospho Ser197) Rabbit pAb
-YP1748
主要信息
Target
MKP-3 Phospho Ser197
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
42kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1748
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MKP-3 (Phospho-Ser197) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DGsPL
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
42kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized peptide derived from human MKP-3 (Phospho-Ser197)
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特异性:
This antibody detects endogenous levels of MKP-3 (Phospho-Ser197) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DGsPL
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基因名称:
DUSP6 MKP3 PYST1
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蛋白名称:
MKP-3 (Phospho-Ser197)
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别名:
Dual specificity protein phosphatase 6 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase PYST1 ;
Mitogen-activated protein kinase phosphatase 3 ;
MAP kinase phosphatase 3 ;
MKP-3 ;
EC 3.1.3.48 ;
Dual specificity protein phosphatase PYST1 ;
Mitogen-activated protein kinase phosphatase 3 ;
MAP kinase phosphatase 3 ;
MKP-3 ;
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背景:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK , SAPK/JNK , p38) , which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases , different tissue distribution and subcellular localization , and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2 , is expressed in a variety of tissues with the highest levels in heart and pancreas , and unlike most other members of this family , is localized in the cytoplasm. Mutations in t
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功能:
Catalytic activity:A phosphoprotein + H (2) O = a protein + phosphate. ,Catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,Function:Inactivates MAP kinases. Has a specificity for the ERK family. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. ,similarity:Contains 1 rhodanese domain. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,
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细胞定位:
Cytoplasm .
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研究领域:
>>MAPK signaling pathway ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
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信号通路
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货号: YP1748
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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