Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CA9

Carbonic anhydrase 9

CA9 ;
G250 ;
MN ;
Carbonic anhydrase 9 ;
Carbonate dehydratase IX ;
Carbonic anhydrase IX ;
CA-IX ;
CAIX ;
Membrane antigen MN ;
P54/58N ;
Renal cell carcinoma-associated antigen G250 ;
RCC-associated antigen G250 ;
pMW1

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014],

response to hypoxia, morphogenesis of an epithelium, one-carbon metabolic process, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to testosterone stimulus, response to drug, secretion, response to steroid hormone stimulus, tissue morphogenesis, epithelium development, response to oxygen levels,

Nucleus . Nucleus, nucleolus . Cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein . Found on the surface microvilli and in the nucleus, particularly in nucleolus.

Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.