Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

BMP7

Bone morphogenetic protein 7

BMP7 ;
OP1 ;
Bone morphogenetic protein 7 ;
BMP-7 ;
Osteogenic protein 1 ;
OP-1 ;
Eptotermin alfa

function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,

cell morphogenesis, cell morphogenesis involved in differentiation, skeletal system development, ossification, eye development, urogenital system development, formation of primary germ layer, mesoderm formation, morphogenesis of a branching structure, kidney development, epithelial to mesenchymal transition, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, cell motion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, gastrulation, pattern specification process, axonogenesis, axon guidance, sensory organ development, salivary gland development, salivary gland morphogenesis, mesoderm development, response to nutrient, negative regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus,embryonic pattern specification, positive regulation of biosynthetic process, positive regulation of signal transduction,response to extracellular stimulus, response to organic substance, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process,positive regulation of gene expression, positive regulation of cell communication, negative regulation of cell development, positive regulation of pathway-restricted SMAD protein phosphorylation, regulation of cell death,positive regulation of cell death, mesenchymal cell development, phosphorylation, regulation of phosphate metabolic process, gland morphogenesis, cell projection organization, neuron differentiation, regulation of ossification,regulation of bone mineralization, positive regulation of bone mineralization, BMP signaling pathway, epithelial cell differentiation, embryonic camera-type eye development, neuron projection development, positive regulation of cellular biosynthetic process, regulation of protein modification process, positive regulation of protein modification process, response to nutrient levels, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, response to estradiol stimulus, cellular component morphogenesis, cell part morphogenesis, response to vitamin, response to vitamin D, tube morphogenesis, exocrine system development, tube development, growth, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, odontogenesis of dentine-containing tooth, odontogenesis, regulation of apoptosis, camera-type eye development, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, response to peptide hormone stimulus, response to estrogen stimulus, regulation of transcription, negative regulation of cell differentiation, positive regulation of cell differentiation, regulation of osteoblast differentiation, positive regulation of osteoblast differentiation, positive regulation of ossification, negative regulation of cell cycle, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, embryonic eye morphogenesis, mesoderm morphogenesis, response to steroid hormone stimulus, embryonic organ morphogenesis,embryonic organ development, eye morphogenesis, camera-type eye morphogenesis, embryonic camera-type eye morphogenesis, embryonic morphogenesis, neuron development, cell morphogenesis involved in neuron differentiation, tissue morphogenesis, gland development, branching morphogenesis of a tube, mesenchymal cell differentiation, neuron projection morphogenesis, cell projection morphogenesis, regulation of neurogenesis, negative regulation of neurogenesis, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, cartilage development, positive regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of RNA metabolic process,positive regulation of RNA metabolic process, regulation of cell cycle, regulation of nervous system development,regulation of cell development, bone development, pathway-restricted SMAD protein phosphorylation, regulation of pathway-restricted SMAD protein phosphorylation, epithelium development, mesenchyme development, regulation of biomineral formation, positive regulation of biomineral formation,

Secreted.

Expressed in the kidney and bladder. Lower levels seen in the brain.