Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by PKB/AKT1 during glucose starvation. Activated by phosphorylation on Thr-211 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. ,Function:Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6 , thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. ,similarity:Contains 1 protein kinase domain. ,tissue specificity:Expressed at high levels in heart and brain , and at lower levels in skeletal muscle , kidney , ovary , placenta , lung and liver. ,
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