Synthesized peptide derived from human CAMKK1/2 (Phospho-Ser458/495)

This antibody detects endogenous CAMKK1 only when phosphorylated at ser458 and endogenous CAMKK2 only when phosphorylated at ser495. .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KRsFG

CAMKK1 CAMKKA

CAMKK1/2 (Phospho-Ser458/495)

Calcium/calmodulin-dependent protein kinase kinase 1 ;
CaM-KK 1 ;
CaM-kinase kinase 1 ;
CaMKK 1 ;
CaM-kinase IV kinase ;
Calcium/calmodulin-dependent protein kinase kinase alpha ;
CaM-KK alpha ;
CaM-kinase kinase alpha ;
CaMKK alpha ;

The product of this gene belongs to the Serine/Threonine protein kinase family , and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Domain:The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. ,Domain:The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates. ,enzyme regulation:Activated by Ca (2+) /calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity) . May be regulated through phosphorylation by CAMK1 and CAMK4. ,Function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 , CAMK1D , CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. ,PTM:Appears to be autophosphorylated in a Ca (2+) /calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca (2+) /calmodulin. In vitro , phosphorylated by CAMK1 and CAMK4. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with CAMK4 and calmodulin. ,

Cytoplasm . Nucleus .

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