Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FLT1

Vascular endothelial growth factor receptor 1

FLT1 ;
FLT ;
FRT ;
VEGFR1 ;
Vascular endothelial growth factor receptor 1 ;
VEGFR-1 ;
Fms-like tyrosine kinase 1 ;
FLT-1 ;
Tyrosine-protein kinase FRT ;
Tyrosine-protein kinase receptor FLT ;
FLT ;
Vascular permeability factor receptor

alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.,tissue specificity:Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.,

MAPKKK cascade, activation of MAPKK activity, angiogenesis, blood vessel development, patterning of blood vessels,response to hypoxia, morphogenesis of a branching structure, vasculature development, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell motion, regulation of muscle contraction, regulation of smooth muscle contraction, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, pattern specification process, female pregnancy, positive regulation of cell proliferation, positive regulation of signal transduction, positive regulation of cell communication, phosphorylation, cell migration, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, regulation of phosphate metabolic process, regulation of cell migration, positive regulation of cell migration, intracellular receptor-mediated signaling pathway, regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, activation of protein kinase activity, positive regulation of kinase activity, tube morphogenesis, tube development, regulation of locomotion, positive regulation of locomotion,regulation of cell proliferation, regulation of phosphorylation, positive regulation of catalytic activity, regulation of kinase activity, regulation of system process, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, blood vessel morphogenesis, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, branching morphogenesis of a tube, cell motility,regulation of phosphorus metabolic process, regulation of cell motion, positive regulation of cell motion, regulation of transferase activity, positive regulation of transferase activity, localization of cell, response to oxygen levels,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 7]: Cytoplasm .

Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).