Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

MMP7

Matrilysin

MMP7 ;
MPSL1 ;
PUMP1 ;
Matrilysin ;
Matrin ;
Matrix metalloproteinase-7 ;
MMP-7 ;
Pump-1 protease ;
Uterine metalloproteinase

catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).,cofactor:Binds 2 calcium ions per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,

proteolysis, collagen catabolic process, collagen metabolic process, regulation of cell proliferation, multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process,

Secreted, extracellular space, extracellular matrix .