Synthesized peptide derived from human p38-γ/δ (Phospho-Tyr185/182)

This antibody detects endogenous levels of p38-γ/δ only when phosphorylated at Tyr185 or thr182,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):TGyVV

MAPK12 ERK6 SAPK3

p38-γ/δ (Phospho-Tyr185/182)

Mitogen-activated protein kinase 12 ;
MAP kinase 12 ;
MAPK 12 ;
Extracellular signal-regulated kinase 6 ;
ERK-6 ;
Mitogen-activated protein kinase p38 gamma ;
MAP kinase p38 gamma ;
Stress-activated protein kinase 3 ;

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Binds 2 magnesium ions. ,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. ,enzyme regulation:Activated by phosphorylation on threonine and tyrosine. ,Function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. ,PTM:Dually phosphorylated on Thr-183 and Tyr-185 , which activates the enzyme. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Mitochondrial when associated with SH3BP5. ,subunit:Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. ,tissue specificity:Highly expressed in skeletal muscle and heart. ,

Cytoplasm. Nucleus. Mitochondrion. Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity) . .

>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>Rap1 signaling pathway ;
>>FoxO signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Oocyte meiosis ;
>>Cellular senescence ;
>>Adrenergic signaling in cardiomyocytes ;
>>VEGF signaling pathway ;
>>Osteoclast differentiation ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>Thermogenesis ;
>>Neurotrophin signaling pathway ;
>>Retrograde endocannabinoid signaling ;
>>Dopaminergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>GnRH signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Prolactin signaling pathway ;
>>Relaxin signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis , secretion and action ;
>>Alcoholic liver disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Yersinia infection ;
>>Leishmaniasis ;
>>Chagas disease ;
>>Toxoplasmosis ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis