Synthesized peptide derived from human ROCK2 (Phospho-Tyr722)

This antibody detects endogenous levels of ROCK2 (Phospho-Tyr722) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KIyES

ROCK2 KIAA0619

ROCK2 (Phospho-Tyr722)

ROCK2 ;
KIAA0619 ;
Rho-associated protein kinase 2 ;
Rho kinase 2 ;
Rho-associated ;
coiled-coil-containing protein kinase 2 ;
Rho-associated,coiled-coil-containing protein kinase II ;
ROCK-II ;
p164 ROCK-2

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis , smooth muscle contraction , the formation of actin stress fibers and focal adhesions , and the activation of the c-fos serum response element. This protein , which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Activated by RHOA binding. ,Function:Protein kinase that phosphorylates a large number of important signaling proteins , and thereby regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction. ,miscellaneous:Inhibited by Y-27632. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 phorbol-ester/DAG-type zinc finger. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 REM (Hr1) repeat. ,subcellular location:Cytoplasmic , and associated with actin microfilaments and the plasma membrane. ,subunit:Homodimer. Binds RHOA that has been activated by GTP binding. Binds IRS1 , RHOB and RHOC. ,

Cytoplasm. Cell membrane ; Peripheral membrane protein . Nucleus. Cytoplasm , cytoskeleton , microtubule organizing center , centrosome. Cytoplasmic , and associated with actin microfilaments and the plasma membrane. .

>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Vascular smooth muscle contraction ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>Focal adhesion ;
>>Tight junction ;
>>Platelet activation ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Oxytocin signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Lipid and atherosclerosis