Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

KDR

Vascular endothelial growth factor receptor 2

KDR ;
FLK1 ;
VEGFR2 ;
Vascular endothelial growth factor receptor 2 ;
VEGFR-2 ;
Fetal liver kinase 1 ;
FLK-1 ;
Kinase insert domain receptor ;
KDR ;
Protein-tyrosine kinase receptor flk-1 ;
CD antigen CD309

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat.,

angiogenesis, ovarian follicle development, blood vessel development, vasculogenesis, morphogenesis of a branching structure, tissue homeostasis, vasculature development, positive regulation of mesenchymal cell proliferation, immune system development, reproductive developmental process, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell motion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, sex differentiation, positive regulation of cell proliferation, regulation of cell shape, gonad development, female gonad development, regulation of mesenchymal cell proliferation, phosphorylation, cell migration, developmental maturation,ovulation cycle process, regulation of cell morphogenesis, hemopoiesis, respiratory tube development, lung development, regulation of cell migration, positive regulation of cell migration, epithelial cell differentiation, regulation of response to external stimulus, positive regulation of response to external stimulus, multicellular organism reproduction, tube morphogenesis, tube development, regulation of locomotion, positive regulation of locomotion,regulation of cell proliferation, homeostatic process, ovulation cycle, surfactant homeostasis, development of primary sexual characteristics, cell fate commitment, endothelial cell differentiation, development of primary female sexual characteristics, female sex differentiation, vascular endothelial growth factor receptor signaling pathway, lung alveolus development, cell maturation, rhythmic process, blood vessel morphogenesis, positive regulation of behavior,hemopoietic or lymphoid organ development, positive regulation of response to stimulus, reproductive structure development, reproductive process in a multicellular organism, branching morphogenesis of a tube, cell motility,multicellular organismal homeostasis, chemical homeostasis within a tissue, chemical homeostasis, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, regulation of behavior, ion homeostasis,regulation of chemotaxis, positive regulation of chemotaxis, regulation of positive chemotaxis, positive regulation of positive chemotaxis, regulation of cell motion, positive regulation of cell motion, localization of cell, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, anatomical structure homeostasis, epithelium development, respiratory system development,

Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.

Detected in cornea (at protein level). Widely expressed.