Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

ENG

Endoglin

ENG ;
END ;
Endoglin ;
CD antigen CD105

disease:Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.,function:Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.,subunit:Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4.,tissue specificity:Endoglin is restricted to endothelial cells in all tissues except bone marrow.,

negative regulation of transcription from RNA polymerase II promoter, chronological cell aging, angiogenesis, blood vessel development, patterning of blood vessels, vasculogenesis, response to hypoxia, morphogenesis of a branching structure, endothelial cell development, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, vasculature development, heart looping, epithelial cell development, heart morphogenesis, circulatory system process, detection of oxygen, regulation of systemic arterial blood pressure, positive regulation of systemic arterial blood pressure, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cell motion, chemotaxis, cell adhesion,cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, pattern specification process, heart development, muscle organ development, aging, cell aging, behavior,locomotory behavior, blood circulation, regulation of blood pressure, negative regulation of cell proliferation, detection of chemical stimulus, response to wounding, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, negative regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication, positive regulation of pathway-restricted SMAD protein phosphorylation,establishment of endothelial blood-brain barrier, cell migration, negative regulation of transcription, regulation of transforming growth factor beta receptor signaling pathway, regulation of phosphate metabolic process, central nervous system vasculogenesis, cellular component disassembly, biological adhesion, extracellular matrix disassembly,regulation of cell adhesion, extracellular matrix organization, BMP signaling pathway, regulation of BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of BMP signaling pathway, epithelial cell differentiation, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of protein modification process, negative regulation of protein modification process, positive regulation of protein modification process, regulation of protein amino acid autophosphorylation, negative regulation of protein amino acid autophosphorylation, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, negative regulation of gene-specific transcription, regulation of gene-specific transcription,regulation of monooxygenase activity, negative regulation of monooxygenase activity, tube morphogenesis, tube development, wound healing, regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation, positive regulation of phosphorylation, taxis, extracellular structure organization, negative regulation of catalytic activity, positive regulation of gene-specific transcription, negative regulation of molecular function,endothelial cell differentiation, regulation of transcription, positive regulation of blood pressure, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of phosphate metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, blood vessel morphogenesis, smooth muscle tissue development, branching morphogenesis of a tube, artery morphogenesis, venous blood vessel morphogenesis, cell motility, regulation of nitric-oxide synthase activity, negative regulation of nitric-oxide synthase activity, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process,positive regulation of protein metabolic process, negative regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process,regulation of oxidoreductase activity, negative regulation of oxidoreductase activity, detection of stimulus, localization of cell, cell chemotaxis, regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of pathway-restricted SMAD protein phosphorylation, epithelium development, muscle tissue development, response to oxygen levels, detection of hypoxia,

Cell membrane ; Single-pass type I membrane protein .

Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).