MNK2 (Phospho Thr244) Rabbit pAb
-YP1705
主要信息
Target
MNK2 Phospho Thr244
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
51kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1705
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MNK2 (Phospho-Thr244) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):IStPE
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
51kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human MNK2 (Phospho-Thr244)
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特异性:
This antibody detects endogenous levels of MNK2 (Phospho-Thr244) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):IStPE
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基因名称:
MKNK2 GPRK7 MNK2
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蛋白名称:
MAP kinase-interacting serine/threonine-protein kinase 2
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别名:
MKNK2 ;
GPRK7 ;
MNK2 ;
MAP kinase-interacting serine/threonine-protein kinase 2 ;
MAP kinase signal-integrating kinase 2 ;
MAPK signal-integrating kinase 2 ;
Mnk2
GPRK7 ;
MNK2 ;
MAP kinase-interacting serine/threonine-protein kinase 2 ;
MAP kinase signal-integrating kinase 2 ;
MAPK signal-integrating kinase 2 ;
Mnk2
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背景:
MAP kinase interacting serine/threonine kinase 2 (MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family , which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs , and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G) . This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E) , thus playing important roles in the initiation of mRNA translation , oncogenic transformation and malignant cell proliferation. In addition to eIF4E , this protein also interacts with von Hippel-Lindau tumor suppressor (VHL) , ring-box 1 (Rbx1) and Cullin2 (Cul2) , which are all components of the CBC (VHL) ubiquitin ligase E3 complex.
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Binds 1 zinc ion per subunit. ,cofactor:Magnesium. ,Function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E , thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. ,PTM:Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2. Isoform 2 interacts with ESR2. ,tissue specificity:Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. ,
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细胞定位:
[Isoform 2]: Nucleus , PML body.; [Isoform 1]: Cytoplasm.
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研究领域:
>>MAPK signaling pathway ;
>>HIF-1 signaling pathway ;
>>Insulin signaling pathway
>>HIF-1 signaling pathway ;
>>Insulin signaling pathway
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信号通路
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货号: YP1705
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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