Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL23A

Interleukin-23 subunit alpha/Interleukin-12 subunit beta

IL23A ;
SGRF ;
Interleukin-23 subunit alpha ;
IL-23 subunit alpha ;
IL-23-A ;
Interleukin-23 subunit p19 ;
IL-23p19 ;
IL12B ;
NKSF2 ;
Interleukin-12 subunit beta ;
IL-12B ;
Cytotoxic lymphocyte maturation factor 40 kDa subunit ;
CLMF p40 ;
IL-12 subunit

developmental stage:Expressed by newborns dendritic cells.,function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.,induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.,similarity:Belongs to the IL-6 superfamily.,subcellular location:Secreted upon association with IL12B.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.,tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).,

cell activation, defense response, inflammatory response, immune response, cell proliferation, response to wounding,response to virus, mononuclear cell proliferation, T cell proliferation, T cell activation, innate immune response,leukocyte activation, lymphocyte activation, lymphocyte proliferation, tissue remodeling, leukocyte proliferation,

Secreted . Secreted upon association with IL12B.

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).