SIK (Phospho Thr182) Rabbit pAb
-YP1685
主要信息
Target
QIK/QSK Phospho Thr182
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
86kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1685
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of SIK (Phospho-Thr182) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PLStW
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
86kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
ERCC1 (1B10) Mouse mAb
YM3078
预览→
抗原&靶点信息
免疫原:
Synthesized peptide derived from human SIK (Phospho-Thr182)
展开内容
特异性:
This antibody detects endogenous levels of SIK (Phospho-Thr182) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PLStW
展开内容
基因名称:
SIK1 SIK SNF1LK
展开内容
蛋白名称:
SIK (Phospho-Thr182)
展开内容
别名:
Serine/threonine-protein kinase SIK1 ;
Salt-inducible kinase 1 ;
SIK-1 ;
Serine/threonine-protein kinase SNF1-like kinase 1 ;
Serine/threonine-protein kinase SNF1LK ;
Salt-inducible kinase 1 ;
SIK-1 ;
Serine/threonine-protein kinase SNF1-like kinase 1 ;
Serine/threonine-protein kinase SNF1LK ;
展开内容
功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. ,Function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators , CRTC1-3. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 UBA domain. ,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ. ,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182. ,
展开内容
细胞定位:
Cytoplasm . Nucleus . Locates to cytoplasm when inactive following cAMP-induced phosphorylation , probably by PKA (PubMed:29211348) .
展开内容
组织表达:
研究领域:
>>Glucagon signaling pathway
展开内容
文献引用（{{totalcount}}）
货号: YP1685
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}