DYRK1A/B (Phospho Tyr321/273) Rabbit pAb
-YP1664
主要信息
Target
DYRK1A/B Phospho Tyr321/273
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
84kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1664
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of DYRK1A only when phosphorylated at Thr321 and DYRK1B only when phosphorylated at thr273..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YQyIQ
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
84kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
ERCC1 (1B10) Mouse mAb
YM3078
预览→
抗原&靶点信息
免疫原:
Synthesized peptide derived from human DYRK1A/B (Phospho-Tyr321/273)
展开内容
特异性:
This antibody detects endogenous levels of DYRK1A only when phosphorylated at Thr321 and DYRK1B only when phosphorylated at thr273..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YQyIQ
展开内容
基因名称:
DYRK1A DYRK MNB MNBH
展开内容
蛋白名称:
DYRK1A/B (Phospho-Tyr321/273)
展开内容
别名:
DYRK1A ;
DYRK ;
MNB ;
MNBH ;
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ;
Dual specificity YAK1-related kinase ;
HP86 ;
Protein kinase minibrain homolog ;
MNBH ;
hMNB
DYRK ;
MNB ;
MNBH ;
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ;
Dual specificity YAK1-related kinase ;
HP86 ;
Protein kinase minibrain homolog ;
MNBH ;
hMNB
展开内容
背景:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence , a protein kinase domain , a leucine zipper motif , and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21 , and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' co
展开内容
功能:
Alternative products:Additional isoforms seem to exist ,Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,developmental stage:Expressed in the developing central nervous system. ,Disease:Overexpressed 1.5-fold in fetal Down syndrome brain. ,enzyme regulation:Inhibited by RANBP9. ,Function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine , threonine and tyrosine residues in its sequence and in exogenous substrates. ,PTM:Autophosphorylated on tyrosine residues. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts RAD54L2/ARIP4 (By similarity) . Interacts with RANBP9. ,tissue specificity:Ubiquitous. Highest levels in skeletal muscle , testis , fetal lung and fetal kidney. ,
展开内容
细胞定位:
Nucleus . Nucleus speckle .
展开内容
文献引用（{{totalcount}}）
货号: YP1664
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}