RBBP8 (Phospho Ser664) Rabbit pAb
-YP1822
主要信息
Target
CTIP Phospho Ser664
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, WB
MW
100kD (Observed)
Conjugate/Modification
Phospho
货号: YP1822
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-200
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of RBBP8 (Phospho Ser664) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DLsQY
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
100kD
修饰
Phospho
克隆性
Polyclonal
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human RBBP8 (Phospho Ser664)
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特异性:
This antibody detects endogenous levels of RBBP8 (Phospho Ser664) Rabbit pAb at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DLsQY
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基因名称:
RBBP8 CTIP
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蛋白名称:
DNA endonuclease RBBP8 (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)
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别名:
DNA endonuclease RBBP8 ;
CtBP-interacting protein ;
CtIP ;
Retinoblastoma-binding protein 8 ;
RBBP-8 ;
Retinoblastoma-interacting protein and myosin-like ;
RIM ;
Sporulation in the absence of SPO11 protein 2 homolog ;
SAE2 ;
CtBP-interacting protein ;
CtIP ;
Retinoblastoma-binding protein 8 ;
RBBP-8 ;
Retinoblastoma-interacting protein and myosin-like ;
RIM ;
Sporulation in the absence of SPO11 protein 2 homolog ;
SAE2 ;
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背景:
RB binding protein 8, endonuclease(RBBP8) Homo sapiens The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],
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功能:
Function:May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,subcellular location:Predominantly nuclear.,subunit:Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein.,
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细胞定位:
Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). .
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研究领域:
>>Homologous recombination
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文献引用（{{totalcount}}）
货号: YP1822
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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