Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFSF10

Tumor necrosis factor ligand superfamily member 10

TNFSF10 ;
APO2L ;
TRAIL ;
Tumor necrosis factor ligand superfamily member 10 ;
Apo-2 ligand ;
Apo-2L ;
TNF-related apoptosis-inducing ligand ;
Protein TRAIL ;
CD antigen CD253

cofactor:Binds 1 zinc ion per trimer.,function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Widespread; most predominant in spleen, lung and prostate.,

apoptosis, induction of apoptosis, immune response, cell-cell signaling, cell death, activation of pro-apoptotic gene products, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death,programmed cell death, induction of programmed cell death, death, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade,

Cell membrane ; Single-pass type II membrane protein . Secreted . Exists both as membrane-bound and soluble form. .

Widespread; most predominant in spleen, lung and prostate.