Synthetic Peptide of Histone H4 (Phospho Ser1)

The antibody detects endogenous Histone H4 (Phospho Ser1) protein.

HIST1H4A/HIST1H4B/HIST1H4C/HIST1H4D/HIST1H4E/HIST1H4F/HIST1H4H/HIST1H4I/HIST1H4J/HIST1H4K/HIST1H4L/HIST2H4A/HIST2H4B/HIST4H4

Histone H4

HIST1H4A ;
H4/A ;
H4FA ;
HIST1H4B ;
H4/I ;
H4FI ;
HIST1H4C ;
H4/G ;
H4FG ;
HIST1H4D ;
H4/B ;
H4FB ;
HIST1H4E ;
H4/J ;
H4FJ ;
HIST1H4F ;
H4/C ;
H4FC ;
HIST1H4H ;
H4/H ;
H4FH ;
HIST1H4I ;
H4/M ;
H4FM ;
HIST1H4J ;
H4/E ;
H4FE ;
HIST1H4K ;
H4/D ;
H4FD ;
HIST1H4L ;
H4/K ;
H4FK ;
HIST2H4A ;
H4/N ;
H4F2 ;
H4FN ;
HIST2H4 ;
HIST2H4B ;
H4/O ;
H4FO ;
HIST4H4 ;
Histone H4

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A , H2B , H3 , and H4) form an octamer , around which approximately 146 bp of DNA is wrapped in repeating units , called nucleosomes. The linker histone , H1 , interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq , Aug 2015] ,

Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin , limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation , DNA repair , DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones , also called histone code , and nucleosome remodeling. ,PTM:Acetylation at Lys-6 , Lys-9 , Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin. ,PTM:Citrullination at Arg-4 by PADI4 impairs methylation. ,PTM:Monomethylated , dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing. ,PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6. ,PTM:Sumoylated , which is associated with transcriptional repression. ,PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. ,similarity:Belongs to the histone H4 family. ,subunit:The nucleosome is a histone octamer containing two molecules each of H2A , H2B , H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. ,

Nucleus. Chromosome.

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