Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CCL5

C-C motif chemokine 5

CCL5 ;
D17S136E ;
SCYA5 ;
C-C motif chemokine 5 ;
EoCP ;
Eosinophil chemotactic cytokine ;
SIS-delta ;
Small-inducible cytokine A5 ;
T cell-specific protein P228 ;
TCP228 ;
T-cell-specific protein RANTES

function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.,induction:By mitogens.,mass spectrometry: PubMed:1380064,mass spectrometry: PubMed:15923218,mass spectrometry:O-glycosylated PubMed:1380064,online information:RANTES entry,polymorphism:The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3.,PTM:N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.,PTM:The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:T-cell and macrophage specific.,

response to molecule of bacterial origin, chronic inflammatory response, regulation of acute inflammatory response,positive regulation of acute inflammatory response, regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, exocytosis, cell motion, chemotaxis, defense response, inflammatory response, immune response,cellular defense response, response to oxidative stress, cell adhesion, cell surface receptor linked signal transduction,G-protein coupled receptor protein signaling pathway, cell-cell signaling, aging, behavior, locomotory behavior,response to wounding, response to virus, response to bacterium, response to endogenous stimulus, response to hormone stimulus, response to organic substance, vesicle-mediated transport, cell migration, cellular homeostasis,biological adhesion, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, leukocyte chemotaxis, positive regulation of defense response, regulation of fever, positive regulation of fever, regulation of heat generation, positive regulation of heat generation, response to corticosteroid stimulus, regulation of response to external stimulus, positive regulation of response to external stimulus, response to lipopolysaccharide, regulation of homeostatic process, positive regulation of homeostatic process, response to insulin stimulus, secretion by cell,response to cytokine stimulus, response to tumor necrosis factor, taxis, response to drug, homeostatic process,response to peptide hormone stimulus, regulation of viral genome replication, negative regulation of viral genome replication, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of osteoclast differentiation, positive regulation of osteoclast differentiation,secretion, lymphocyte chemotaxis, negative regulation of viral reproduction, response to steroid hormone stimulus,positive regulation of response to stimulus, cell motility, chemical homeostasis, regulation of inflammatory response,positive regulation of inflammatory response, regulation of viral reproduction, ion homeostasis, leukocyte migration,positive regulation of developmental process, positive regulation of multicellular organismal process, response to glucocorticoid stimulus, localization of cell, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, cell chemotaxis,

Secreted.

Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.