Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

SERPINE1

Plasminogen activator inhibitor 1

SERPINE1 ;
PAI1 ;
PLANH1 ;
Plasminogen activator inhibitor 1 ;
PAI ;
PAI-1 ;
Endothelial plasminogen activator inhibitor ;
Serpin E1

disease:Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma.,disease:High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.,function:This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.,online information:Plasminogen activator inhibitor-1 entry,PTM:Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.,similarity:Belongs to the serpin family.,subunit:Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.,tissue specificity:Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.,

response to reactive oxygen species, chronological cell aging, response to oxidative stress, aging, cell aging, blood coagulation, hemostasis, response to wounding, response to inorganic substance, regulation of blood coagulation,negative regulation of blood coagulation, regeneration, regulation of response to external stimulus, carbohydrate homeostasis, growth, wound healing, regulation of cell proliferation, tissue regeneration, homeostatic process,glucose homeostasis, fibrinolysis, regulation of angiogenesis, developmental growth, chemical homeostasis,coagulation, regulation of coagulation, negative regulation of coagulation, regulation of body fluid levels, negative regulation of multicellular organismal process,

Secreted .

Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.