PTRF (Phospho Tyr156) Rabbit pAb
-YP1774
主要信息
Target
PTRF Phospho Tyr156
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
55kD (Observed)
Conjugate/Modification
Phospho
货号: YP1774
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of PTRF (Phospho-Tyr156) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MIyQD
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized peptide derived from human PTRF (Phospho-Tyr156)
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特异性:
This antibody detects endogenous levels of PTRF (Phospho-Tyr156) at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):MIyQD
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基因名称:
PTRF FKSG13
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蛋白名称:
PTRF (Phospho-Tyr156)
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别名:
Polymerase I and transcript release factor ;
Cavin-1 ;
Cavin-1 ;
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背景:
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrop
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功能:
Function:Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.,PTM:Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.,PTM:Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity.,similarity:Belongs to the PTRF/SDPR family.,subcellular location:Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with RNA polymerase I and TTF1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm.,
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细胞定位:
Membrane, caveola . Cell membrane . Microsome . Endoplasmic reticulum . Cytoplasm, cytosol . Mitochondrion . Nucleus . Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity). .
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文献引用（{{totalcount}}）
货号: YP1774
规格
价格
货期
数量
200μL
￥4,680.00
两周
0
100μL
￥2,800.00
两周
0
50μL
￥1,500.00
两周
0
加入购物车
已收藏
收藏
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