Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL21

Interleukin-21

IL21 ;
Interleukin-21 ;
IL-21 ;
Za11

function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,

regulation of cytokine production, positive regulation of cytokine production, regulation of leukocyte mediated cytotoxicity, positive regulation of leukocyte mediated cytotoxicity, positive regulation of immune system process,regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process,positive regulation of immune effector process, regulation of production of molecular mediator of immune response,positive regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, positive regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, positive regulation of lymphocyte mediated immunity, regulation of natural killer cell mediated immunity, positive regulation of natural killer cell mediated immunity, regulation of cytokine production during immune response, positive regulation of cytokine production during immune response, regulation of natural killer cell cytokine production, positive regulation of natural killer cell cytokine production, positive regulation of cell proliferation, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, developmental maturation, positive regulation of cellular biosynthetic process, regulation of cell killing,positive regulation of cell killing, positive regulation of defense response, regulation of interferon-gamma production,regulation of interleukin-10 production, positive regulation of interleukin-10 production, regulation of natural killer cell activation, positive regulation of natural killer cell activation, regulation of natural killer cell differentiation, positive regulation of natural killer cell differentiation, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, regulation of cytokine biosynthetic process, positive regulation of T cell proliferation,positive regulation of cytokine biosynthetic process, regulation of cell proliferation, regulation of T cell proliferation,regulation of natural killer cell mediated cytotoxicity, regulation of interferon-gamma biosynthetic process, positive regulation of interferon-gamma biosynthetic process, regulation of innate immune response, positive regulation of innate immune response, positive regulation of cell differentiation, regulation of lymphocyte differentiation, positive regulation of lymphocyte differentiation, positive regulation of natural killer cell mediated cytotoxicity, cell maturation,positive regulation of response to stimulus, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, positive regulation of immune response, regulation of T cell activation, regulation of cell activation,positive regulation of cell activation, positive regulation of T cell activation, positive regulation of developmental process, positive regulation of multicellular organismal process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation,

Secreted .

Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.